CORIN

Across TCGA cell cohorts, CORIN mutation is significantly associated with the RNA expression of many other genes, with 603 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CORIN-associated genes across cancer lineages are PHF7, CAAP1, and LTF. Each is linked with CORIN in more than 1 cancer types. Because this analysis shows association rather than direction, both CORIN-to-partner and partner-to-CORIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF7 grouped by CORIN-low versus CORIN-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CORIN→partner) and Y-score (partner→CORIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PHF7 →	+0.632	+2.043	.003	.008	3	2
SKIN	CAAP1 →	+0.613	+2.129	.006	.007	3	2
SKIN	LTF →	+0.447	+2.600	.002	.006	3	2
LARGE_INTESTINE	TTC5 →	+0.646	+2.502	.003	.005	3	2
LARGE_INTESTINE	BCL7A →	+0.706	+3.169	.006	.009	3	2
LARGE_INTESTINE	C12orf57 →	+0.796	+3.169	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 603 associations by consensus.

PHF7 by CORIN expression — SKIN

Explore this box plot interactively →