CORIN

Across TCGA patient cohorts, CORIN mutation is significantly associated with the RNA expression of many other genes, with 3,705 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CORIN-associated genes across cancer lineages are UBE2S, FOXM1, and TSPY26P. Each is linked with CORIN in more than 3 cancer types. Because this analysis shows association rather than direction, both CORIN-to-partner and partner-to-CORIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2S grouped by CORIN-low versus CORIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CORIN→partner) and Y-score (partner→CORIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBE2S →	+0.447	+1.572	.006	<.001	3	4
UCEC	FOXM1 →	+0.619	+1.562	.001	<.001	3	4
SKCM	TSPY26P →	-0.600	-1.409	.002	.001	3	4
UCEC	HROB →	+0.389	+2.470	.003	<.001	3	4
READ	RPSAP27 →	+0.175	+4.626	<.001	.004	3	3
UCEC	ME3 →	-0.719	-2.370	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,705 associations by consensus.

UBE2S by CORIN expression — UCEC

Explore this box plot interactively →