Q-omics provides the consensus-scored COPS5 profile across patient tissues and cancer cell-line models. COPS5 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, COPS5 is differentially expressed in 15, with the highest sampling consensus in HNSC. Additionally, COPS5 RNA expression shows 19,518 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight UVM, HNSC, and ACC as cancer lineages where COPS5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for COPS5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes COPS5 survival associations across molecular data types. COPS5 RNA expression shows survival associations in the most cancer types (26), followed by mass-spec protein abundance (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible COPS5 RNA expression–survival associations across cancer types. High COPS5 expression shows unfavorable associations in UVM, KICH, LIHC, KIRP, LGG and BRCA. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for COPS5 RNA expression.
This table summarizes COPS5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 8. The strongest signals are observed in KIRC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for COPS5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. COPS5 shows higher tumor expression in HNSC, KIRC, LIHC, BLCA, STAD and LUSC. The HNSC box plot shows higher COPS5 RNA expression in tumor versus normal tissue (log2 FC = +0.863, t-test p < 0.001).
This table shows molecular features associated with COPS5 in patient tissues and cancer cell lines. In patient samples, COPS5 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, COPS5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in CNS and UPPER_AERODIGESTIVE_TRACT.
