COPS5

Across TCGA cell cohorts, COPS5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,610 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible COPS5-associated GO terms across cancer lineages are Blastocyst growth, Negative regulation of protein localization to centrosome, and Regulation of mitotic centrosome separation. Each is linked with COPS5 in more than 14 cancer types. Because this analysis shows association rather than direction, both COPS5-to-partner and partner-to-COPS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Blastocyst growth grouped by COPS5-low versus COPS5-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS5→partner) and Y-score (partner→COPS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Blastocyst growth →	+0.160	+0.677	<.001	<.001	3	15
LARGE_INTESTINE	Negative regulation of protein localization to centrosome →	+0.097	+0.548	<.001	<.001	3	12
BLOOD_Leukemia	Regulation of mitotic centrosome separation →	+0.093	+0.548	.002	<.001	2	11
BLOOD_Leukemia	Proteasome assembly →	+0.063	+0.384	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Intracellular distribution of mitochondria →	+0.224	+0.849	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Regulation of establishment of protein localization to chromosome →	+0.179	+0.875	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,610 associations by consensus.

Blastocyst growth by COPS5 expression — PANCREAS

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