COPS5

Across TCGA pan-cancer cohorts, COPS5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COPS5 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COPS5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COPS5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

LUAD, CCRCC, and COAD are the cancer types where COPS5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.247	0.805	.001	32	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.355	.012	22	view →
COAD	DFS	Median	III,IV	1.000	0.838	.036	6	view →
LSCC	DFS	Median	All	0.883	0.727	.016	3	view →
UCEC	DFS	Tertile	All	0.913	0.707	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COPS5–LUAD (DFS)

Open the LUAD breakdown →