COPS5

Across TCGA patient cohorts, COPS5 mutation is significantly associated with the RNA expression of many other genes, with 3,174 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPS5-associated genes across cancer lineages are MRPS23, SHMT2, and ALYREF. Each is linked with COPS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS5-to-partner and partner-to-COPS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS23 grouped by COPS5-low versus COPS5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS5→partner) and Y-score (partner→COPS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS23 →	+0.426	+3.269	.007	<.001	3	2
UCEC	SHMT2 →	+0.817	+3.606	<.001	.001	3	2
UCEC	ALYREF →	+0.571	+3.906	.007	<.001	3	2
UCEC	KMT5A →	+0.493	+2.595	<.001	<.001	3	2
UCEC	DIABLO →	+0.502	+2.955	<.001	<.001	3	2
UCEC	CDCA2 →	+1.027	+3.721	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,174 associations by consensus.

MRPS23 by COPS5 expression — UCEC

Explore this box plot interactively →