COPS5

Across TCGA patient cohorts, COPS5 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPS5-associated genes across cancer lineages are p21, 14-3-3_beta, and eEF2. Each is linked with COPS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS5-to-partner and partner-to-COPS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by COPS5-low versus COPS5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS5→partner) and Y-score (partner→COPS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.169	+3.335	.025	.005	3	2
UCEC	14-3-3_beta →	-0.089	-2.295	.023	.033	3	1
UCEC	eEF2 →	+0.417	+2.459	.002	.018	3	1
UCEC	EGFR_pY1068 →	-0.328	-2.502	<.001	.002	3	1
UCEC	eIF4G →	+0.321	+2.000	.008	.010	3	1
UCEC	A-Raf_pS299 →	-0.167	-2.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

p21 by COPS5 expression — UCEC

Explore this box plot interactively →