COPS5

Across TCGA cell cohorts, COPS5 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COPS5-associated genes across cancer lineages are BRDT, SAXO1, and ENPP6. Each is linked with COPS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS5-to-partner and partner-to-COPS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRDT grouped by COPS5-low versus COPS5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS5→partner) and Y-score (partner→COPS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BRDT →	+0.100	+3.333	<.001	.009	3	1
LARGE_INTESTINE	SAXO1 →	+0.043	+3.556	.001	.007	3	1
LARGE_INTESTINE	ENPP6 →	+0.034	+3.115	.001	.004	3	1
LARGE_INTESTINE	HIGD2B →	+0.048	+3.724	.002	.004	3	1
LARGE_INTESTINE	FAM153B →	+0.441	+3.618	.001	.003	3	1
LARGE_INTESTINE	FREM3 →	+0.095	+3.376	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

BRDT by COPS5 expression — LARGE_INTESTINE

Explore this box plot interactively →