chromosome 12 open reading frame 54Genealiases: HSD-29 · HSD-30
Q-omics provides the consensus-scored C12orf54 profile across patient tissues and cancer cell-line models. C12orf54 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, C12orf54 is differentially expressed in 13, with the highest sampling consensus in KICH. Additionally, C12orf54 RNA expression shows 14,000 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight MESO, KICH, and UVM as cancer lineages where C12orf54 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C12orf54 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C12orf54 survival associations across molecular data types. C12orf54 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C12orf54 RNA expression–survival associations across cancer types. High C12orf54 expression shows unfavorable associations in MESO and DLBC, but favorable associations in LGG, PAAD, BRCA and ACC. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify MESO as the clearest survival context for C12orf54 RNA expression.
This table summarizes C12orf54 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for C12orf54. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C12orf54 shows lower tumor expression in KICH, BRCA, KIRP, LUAD and UCEC and higher tumor expression in LUSC. The KICH box plot shows higher C12orf54 RNA expression in normal versus tumor tissue (log2 FC = −0.273, t-test p < 0.001).
This table shows molecular features associated with C12orf54 in patient tissues and cancer cell lines. In patient samples, C12orf54 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, C12orf54 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in SKIN and UPPER_AERODIGESTIVE_TRACT.
