C12orf54

Across TCGA pan-cancer cohorts, C12orf54 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated C12orf54 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher C12orf54 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C12orf54 expression acts as an unfavorable survival marker.

SKCM, GBM, and SARC are the cancer types where C12orf54 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.179	0.781	<.001	9	view →
GBM	DFS	Median	All	0.052	0.257	.002	6	view →
SARC	DFS	Median	All	0.101	0.632	.011	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

C12orf54–SKCM (OS)

Open the SKCM breakdown →