C12orf54

Across TCGA patient cohorts, C12orf54 mutation is significantly associated with the RNA expression of many other genes, with 131 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible C12orf54-associated genes across cancer lineages are GSTA6P, RNA5SP243, and HMGB1P28. Each is linked with C12orf54 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf54-to-partner and partner-to-C12orf54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSTA6P grouped by C12orf54-low versus C12orf54-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf54→partner) and Y-score (partner→C12orf54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	GSTA6P →	+0.096	+5.010	<.001	.009	3	2
BLCA	RNA5SP243 →	+0.904	+4.331	.004	.007	3	2
UCEC	HMGB1P28 →	+0.461	+2.561	<.001	.006	3	2
SKCM	C11orf45 →	-0.492	-3.440	.006	.005	3	2
CESC	RNA5SP325 →	+0.378	+6.837	<.001	<.001	3	1
CESC	RNU6-275P →	+0.456	+6.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 131 associations by consensus.

GSTA6P by C12orf54 expression — CESC

Explore this box plot interactively →