C12orf54

Across TCGA pan-cancer cohorts, C12orf54 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated C12orf54 data layer compared with 3 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher C12orf54 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C12orf54 expression acts as an unfavorable survival marker, although some lineages such as LGG and PAAD show a favorable association.

MESO, LGG, and PAAD are the cancer types where C12orf54 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	II,III,IV	0.411	0.748	.002	49	view →
LGG	OS	Tertile	All	0.528	0.364	<.001	41	view →
PAAD	DFS	Quartile	All	0.543	0.262	<.001	39	view →
BRCA	DFS	Tertile	All	0.548	0.446	.016	30	view →
ACC	OS	Quartile	II,III,IV	0.736	0.317	.014	25	view →
DLBC	DFS	Quartile	All	0.536	1.000	.005	22	view →
LUAD	DFS	Quartile	II,III,IV	0.640	0.128	.017	21	view →
BLCA	DFS	Median	IV	0.442	0.263	.005	15	view →
KIRC	DFS	Quartile	IV	0.421	0.728	.017	11	view →
KICH	OS	Quartile	All	0.828	1.000	.035	10	view →
LAML	DFS	Median	All	0.310	0.459	.033	10	view →
OV	OS	Median	IV	0.508	0.696	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

C12orf54–MESO (OS)

Open the MESO breakdown →