C12orf54

Across TCGA patient cohorts, C12orf54 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible C12orf54-associated genes across cancer lineages are Smac, Smad4, and Claudin-7. Each is linked with C12orf54 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf54-to-partner and partner-to-C12orf54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smac grouped by C12orf54-low versus C12orf54-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf54→partner) and Y-score (partner→C12orf54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Smac →	+0.396	+3.339	.004	.005	3	1
SKCM	Smad4 →	+0.184	+3.012	.001	.018	3	1
SKCM	Claudin-7 →	+0.332	+3.356	<.001	.005	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Smac by C12orf54 expression — SKCM

Explore this box plot interactively →