Q-omics provides the consensus-scored ASXL2 profile across patient tissues and cancer cell-line models. ASXL2 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in SCLC. Among the 18 cancer types available for tumor–normal comparison, ASXL2 is differentially expressed in 12, with the highest sampling consensus in HNSC. Additionally, ASXL2 RNA expression shows 21,144 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight SCLC, HNSC, and ACC as cancer lineages where ASXL2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ASXL2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ASXL2 survival associations across molecular data types. ASXL2 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (6) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ASXL2 RNA expression–survival associations across cancer types. High ASXL2 expression shows unfavorable associations in MESO, ACC and BLCA, but favorable associations in SCLC, KIRC and HNSC. The SCLC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SCLC as the clearest survival context for ASXL2 RNA expression.
This table summarizes ASXL2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 3. The strongest signals are observed in HNSC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for ASXL2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ASXL2 shows lower tumor expression in THCA and higher tumor expression in HNSC, LIHC, CHOL, KIRP and BLCA. The HNSC box plot shows higher ASXL2 RNA expression in tumor versus normal tissue (log2 FC = +0.761, t-test p < 0.001).
This table shows molecular features associated with ASXL2 in patient tissues and cancer cell lines. In patient samples, ASXL2 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, ASXL2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and BONE.
