ASXL2

Across TCGA pan-cancer cohorts, ASXL2 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ASXL2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where ASXL2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ASXL2 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LSCC, CCRCC, and COAD are the cancer types where ASXL2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASXL2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.260	<.001	7	view →
CCRCC	Male	All	+0.278	<.001	6	view →
COAD	All	All	−0.681	.012	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

ASXL2–LSCC

Open the LSCC breakdown →