ASXL2

Across TCGA patient cohorts, ASXL2 mutation is significantly associated with the RNA expression of many other genes, with 5,160 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASXL2-associated genes across cancer lineages are SEC13, ALYREF, and UBE2L3. Each is linked with ASXL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ASXL2-to-partner and partner-to-ASXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC13 grouped by ASXL2-low versus ASXL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASXL2→partner) and Y-score (partner→ASXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC13 →	+0.361	+2.354	<.001	<.001	3	5
UCEC	ALYREF →	+0.424	+1.847	.004	<.001	3	4
UCEC	UBE2L3 →	+0.259	+2.531	<.001	<.001	3	4
UCEC	RPL23AP7 →	+0.244	+2.022	.007	.002	3	4
UCEC	GCAT →	+0.462	+1.669	.001	<.001	3	4
COAD	TAF13 →	+0.693	+3.241	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,160 associations by consensus.

SEC13 by ASXL2 expression — UCEC

Explore this box plot interactively →