ASXL2

Across TCGA pan-cancer cohorts, ASXL2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ASXL2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ASXL2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ASXL2 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where ASXL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASXL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.761	<.001	11	view →
LIHC	All	II,III,IV	+0.998	<.001	9	view →
THCA	All	All	−0.425	<.001	7	view →
CHOL	All	II,III,IV	+2.085	<.001	5	view →
KIRP	Female	II,III,IV	+0.786	.021	5	view →
BLCA	Female	All	+0.565	.014	5	view →
LUSC	All	All	+0.407	<.001	5	view →
STAD	All	II,III,IV	+0.695	.001	4	view →
UCEC	All	All	−0.402	.042	2	view →
COAD	Male	All	+0.294	.035	2	view →
ESCA	Female	All	+1.009	.009	1	view →
LUAD	Male	All	+0.351	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ASXL2–HNSC

Open the HNSC breakdown →