ASXL2

Across TCGA cell cohorts, ASXL2 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASXL2-associated genes across cancer lineages are SPATA48, DIPK2B, and DEFA4. Each is linked with ASXL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASXL2-to-partner and partner-to-ASXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA48 grouped by ASXL2-low versus ASXL2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASXL2→partner) and Y-score (partner→ASXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPATA48 →	+0.565	+2.977	.001	.004	3	2
LUNG_NSCLC_LUAD	DIPK2B →	+0.089	+4.727	<.001	<.001	3	2
LUNG_NSCLC_LUAD	DEFA4 →	+0.021	+4.078	<.001	.009	3	2
PANCREAS	UGT2B10 →	+0.402	+5.000	<.001	.006	3	1
SKIN	SLC22A9 →	+0.023	+3.688	<.001	.002	3	1
SKIN	SPDYC →	+0.517	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

SPATA48 by ASXL2 expression — BLOOD_Leukemia

Explore this box plot interactively →