Q-omics provides the consensus-scored ZNF430 profile across patient tissues and cancer cell-line models. ZNF430 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, ZNF430 is differentially expressed in 11, with the highest sampling consensus in LIHC. Additionally, ZNF430 RNA expression shows 21,194 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, LIHC, and ACC as cancer lineages where ZNF430 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ZNF430 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ZNF430 survival associations across molecular data types. ZNF430 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (6) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ZNF430 RNA expression–survival associations across cancer types. High ZNF430 expression shows unfavorable associations in UVM, but favorable associations in KIRC, HNSC, SKCM, UCS and THYM. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for ZNF430 RNA expression.
This table summarizes ZNF430 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 6. The strongest signals are observed in LIHC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for ZNF430. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ZNF430 shows lower tumor expression in KICH and higher tumor expression in LIHC, CHOL, BLCA, THCA and COAD. The LIHC box plot shows higher ZNF430 RNA expression in tumor versus normal tissue (log2 FC = +0.516, t-test p < 0.001).
This table shows molecular features associated with ZNF430 in patient tissues and cancer cell lines. In patient samples, ZNF430 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, ZNF430 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in BONE and BLOOD_Leukemia.
