ZNF430

Across TCGA cell cohorts, ZNF430 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ZNF430-associated genes across cancer lineages are FSHB, SIGLEC14, and NKX2-4. Each is linked with ZNF430 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF430-to-partner and partner-to-ZNF430 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSHB grouped by ZNF430-low versus ZNF430-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF430→partner) and Y-score (partner→ZNF430) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FSHB →	+0.035	+4.614	<.001	.004	3	1
PANCREAS	SIGLEC14 →	+0.046	+4.011	<.001	.009	3	1
BREAST	NKX2-4 →	+0.139	+4.672	<.001	.002	3	1
BREAST	ITGAD →	+0.115	+4.199	<.001	.007	3	1
BREAST	ZNF479 →	+0.043	+4.199	.003	.007	3	1
BREAST	NCR1 →	+0.195	+4.199	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

FSHB by ZNF430 expression — PANCREAS

Explore this box plot interactively →