ZNF430

Across TCGA cell cohorts, ZNF430 mutation is significantly associated with the mutation status of many other genes, with 2,269 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF430-associated genes across cancer lineages are TRAM1, POT1, and KIF26B. Each is linked with ZNF430 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF430-to-partner and partner-to-ZNF430 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAM1 grouped by ZNF430-low versus ZNF430-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF430→partner) and Y-score (partner→ZNF430) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TRAM1 →	+4.857	+4.297	.009	.009	1	3
CNS	POT1 →	+5.044	+5.614	.003	.003	1	3
CNS	KIF26B →	+4.459	+5.277	.005	.005	1	3
CNS	ROBO2 →	+4.044	+5.000	.008	.008	1	3
BREAST	CHD1 →	+4.857	+4.297	.009	.009	1	3
SKIN	FOXB2 →	+4.824	+5.392	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,269 associations by consensus.

TRAM1 by ZNF430 expression — BREAST

Explore this box plot interactively →