ZNF430

Across TCGA patient cohorts, ZNF430 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF430-associated genes across cancer lineages are Rictor_pT1135, ATM, and JNK_pT183_Y185. Each is linked with ZNF430 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF430-to-partner and partner-to-ZNF430 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by ZNF430-low versus ZNF430-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF430→partner) and Y-score (partner→ZNF430) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.101	-2.700	.028	.006	3	2
UCEC	ATM →	-0.490	-2.000	.016	.032	3	2
UCEC	JNK_pT183_Y185 →	-0.165	-1.986	.030	.032	3	1
UCEC	Ku80 →	+0.337	+3.469	.001	.002	3	1
UCEC	Notch1 →	+0.191	+3.013	.002	.018	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.435	-1.986	.031	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Rictor_pT1135 by ZNF430 expression — UCEC

Explore this box plot interactively →