zinc finger protein 280DGenealiases: SUHW4 · ZNF634
Q-omics provides the consensus-scored ZNF280D profile across patient tissues and cancer cell-line models. ZNF280D expression is associated with patient survival in 30 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, ZNF280D is differentially expressed in 10, with the highest sampling consensus in LIHC. Additionally, ZNF280D RNA expression shows 21,782 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, LIHC, and ACC as cancer lineages where ZNF280D shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ZNF280D — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ZNF280D survival associations across molecular data types. ZNF280D RNA expression shows survival associations in the most cancer types (30), followed by mutation status (4) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ZNF280D RNA expression–survival associations across cancer types. High ZNF280D expression shows unfavorable associations in ACC, UVM, CESC and KICH, but favorable associations in KIRC and BRCA. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for ZNF280D RNA expression.
This table summarizes ZNF280D tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 4. The strongest signals are observed in THCA for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for ZNF280D. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ZNF280D shows lower tumor expression in THCA, UCEC, BRCA and KICH and higher tumor expression in LIHC and CHOL. The LIHC box plot shows higher ZNF280D RNA expression in tumor versus normal tissue (log2 FC = +0.713, t-test p < 0.001).
This table shows molecular features associated with ZNF280D in patient tissues and cancer cell lines. In patient samples, ZNF280D shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, ZNF280D RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in CNS and UPPER_AERODIGESTIVE_TRACT.
