ZNF280D

Across TCGA pan-cancer cohorts, ZNF280D mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF280D data layer compared with 30 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZNF280D mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZNF280D expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, GBM, and CCRCC are the cancer types where ZNF280D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.844	0.495	.007	17	view →
GBM	OS	Median	All	0.733	0.394	.014	9	view →
CCRCC	OS	Median	III,IV	0.597	1.000	.013	4	view →
PDAC	DFS	Median	II,III,IV	0.841	0.389	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF280D–LUAD (OS)

Open the LUAD breakdown →