ZNF280D

Across TCGA pan-cancer cohorts, ZNF280D Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF280D data layer compared with 30 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ZNF280D Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF280D expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

KIRP, STAD, and UCEC are the cancer types where ZNF280D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.037	0.783	<.001	13	view →
STAD	DFS	Median	III,IV	0.841	0.326	.026	13	view →
UCEC	DFS	Median	All	0.946	0.614	.007	10	view →
SKCM	DFS	Median	III,IV	0.015	0.648	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF280D–KIRP (DFS)

Open the KIRP breakdown →