ZNF280D

Across TCGA patient cohorts, ZNF280D mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF280D-associated genes across cancer lineages are Notch1, p27_pT198, and p70-S6K. Each is linked with ZNF280D in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF280D-to-partner and partner-to-ZNF280D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ZNF280D-low versus ZNF280D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF280D→partner) and Y-score (partner→ZNF280D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.132	+1.594	.001	.010	3	3
UCEC	p27_pT198 →	+0.077	+1.378	.015	.008	3	3
UCEC	p70-S6K →	+0.136	+1.211	.018	.014	3	2
UCEC	PCNA →	+0.219	+1.378	<.001	.008	3	2
UCEC	TFRC →	+0.419	+2.807	.008	.002	3	2
UCEC	ATM →	-0.473	-1.847	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Notch1 by ZNF280D expression — UCEC

Explore this box plot interactively →