ZNF280D

Across TCGA pan-cancer cohorts, ZNF280D RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated ZNF280D data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZNF280D RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZNF280D expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, ACC, and UVM are the cancer types where ZNF280D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Quartile	All	0.768	0.574	<.001	87	view →
ACC	DFS	Median	All	0.375	0.788	<.001	57	view →
UVM	DFS	Median	III,IV	0.244	0.751	<.001	52	view →
CESC	DFS	Quartile	All	0.447	0.747	.005	36	view →
KICH	DFS	Median	II,III,IV	0.554	0.922	.003	31	view →
BRCA	DFS	Quartile	III,IV	0.937	0.763	.003	29	view →
THYM	OS	Quartile	All	1.000	0.622	.004	19	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	17	view →
KIRP	DFS	Quartile	All	0.637	0.773	.008	14	view →
DLBC	DFS	Median	All	0.610	0.926	.007	14	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →
UCS	DFS	Tertile	IV	0.981	0.361	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

ZNF280D–KIRC (OS)

Open the KIRC breakdown →