ZNF280D

Across TCGA patient cohorts, ZNF280D mutation is significantly associated with the RNA expression of many other genes, with 2,955 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF280D-associated genes across cancer lineages are BUB3, POC1A, and NTMT1. Each is linked with ZNF280D in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF280D-to-partner and partner-to-ZNF280D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by ZNF280D-low versus ZNF280D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF280D→partner) and Y-score (partner→ZNF280D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.354	+1.882	<.001	.001	3	3
UCEC	POC1A →	+0.420	+1.954	.004	<.001	3	3
UCEC	NTMT1 →	+0.536	+2.044	<.001	<.001	3	3
UCEC	UBE2L3 →	+0.260	+1.660	.001	.003	3	3
SKCM	RNA5SP241 →	+0.257	+2.730	<.001	.002	3	3
LUAD	RNU6-522P →	+1.937	+5.044	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,955 associations by consensus.

BUB3 by ZNF280D expression — UCEC

Explore this box plot interactively →