zinc finger protein 141Genealiases: D4S90 · pHZ-44
Q-omics provides the consensus-scored ZNF141 profile across patient tissues and cancer cell-line models. ZNF141 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, ZNF141 is differentially expressed in 8, with the highest sampling consensus in THCA. Additionally, ZNF141 RNA expression shows 20,247 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UCS, THCA, and UVM as cancer lineages where ZNF141 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ZNF141 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ZNF141 survival associations across molecular data types. ZNF141 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (5) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ZNF141 RNA expression–survival associations across cancer types. High ZNF141 expression shows unfavorable associations in LIHC and UVM, but favorable associations in UCS, HNSC, LUAD and BRCA. The UCS Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCS as the clearest survival context for ZNF141 RNA expression.
This table summarizes ZNF141 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for ZNF141. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ZNF141 shows lower tumor expression in THCA, LUAD and COAD and higher tumor expression in HNSC, CHOL and PRAD. The THCA box plot shows higher ZNF141 RNA expression in normal versus tumor tissue (log2 FC = −0.560, t-test p < 0.001).
This table shows molecular features associated with ZNF141 in patient tissues and cancer cell lines. In patient samples, ZNF141 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, ZNF141 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and BLOOD_Lymphoma.
