ZNF141

Across TCGA pan-cancer cohorts, ZNF141 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ZNF141’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF141 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF141 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, HNSC, and CHOL are the cancer types where ZNF141 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF141 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.560	<.001	8	view →
HNSC	All	II,III,IV	+0.281	.003	6	view →
CHOL	All	All	+1.221	<.001	3	view →
LUAD	Female	II,III,IV	−0.266	.044	2	view →
COAD	All	All	−0.262	.045	2	view →
PRAD	All	All	+0.241	.013	2	view →
KIRP	Male	All	−0.418	.048	1	view →
KIRC	Male	III,IV	−0.285	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ZNF141–THCA

Open the THCA breakdown →