ZNF141

Across TCGA patient cohorts, ZNF141 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF141-associated genes across cancer lineages are PCNA, mTOR_pS2448, and p62 Lck ligand. Each is linked with ZNF141 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF141-to-partner and partner-to-ZNF141 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ZNF141-low versus ZNF141-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF141→partner) and Y-score (partner→ZNF141) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.248	+2.000	.008	.030	3	2
UCEC	mTOR_pS2448 →	-0.141	-2.115	.031	.019	3	1
UCEC	p62 Lck ligand →	+0.356	+2.594	.012	.006	3	1
UCEC	AMPK_pT172 →	+0.359	+2.128	.046	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.652	+2.341	.011	.019	3	1
UCEC	CD49b →	-0.291	-3.150	.019	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PCNA by ZNF141 expression — UCEC

Explore this box plot interactively →