zinc finger protein, FOG family member 1Genealiases: FOG · FOG1 · PRDM18 · ZC2HC11A · ZNF89A
Q-omics provides the consensus-scored ZFPM1 profile across patient tissues and cancer cell-line models. ZFPM1 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, ZFPM1 is differentially expressed in 10, with the highest sampling consensus in COAD. Additionally, ZFPM1 RNA expression shows 17,358 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight UVM, COAD, and TGCT as cancer lineages where ZFPM1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ZFPM1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ZFPM1 survival associations across molecular data types. ZFPM1 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (4) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ZFPM1 RNA expression–survival associations across cancer types. High ZFPM1 expression shows unfavorable associations in COAD, ESCA and ACC, but favorable associations in UVM, SCLC and BLCA. The UVM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .003). Together, the overview and detailed table identify UVM as the clearest survival context for ZFPM1 RNA expression.
This table summarizes ZFPM1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 3. The strongest signals are observed in HNSC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for ZFPM1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ZFPM1 shows higher tumor expression in COAD, HNSC, BRCA, STAD, KIRP and LIHC. The COAD box plot shows higher ZFPM1 RNA expression in tumor versus normal tissue (log2 FC = +1.277, t-test p < 0.001).
This table shows molecular features associated with ZFPM1 in patient tissues and cancer cell lines. In patient samples, ZFPM1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, ZFPM1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and LARGE_INTESTINE.
