ZFPM1

Across TCGA patient cohorts, ZFPM1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ZFPM1-associated genes across cancer lineages are MEK1, 4E-BP1, and FASN. Each is linked with ZFPM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFPM1-to-partner and partner-to-ZFPM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZFPM1-low versus ZFPM1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFPM1→partner) and Y-score (partner→ZFPM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MEK1 →	+0.200	+3.000	.033	.035	3	2
COAD	4E-BP1 →	+0.224	+2.178	.029	.035	3	2
COAD	FASN →	+0.417	+3.330	.023	.005	3	1
COAD	GSK3-a-b →	+0.184	+3.012	.010	.018	3	1
COAD	RAD51 →	+0.151	+3.330	.041	.005	3	1
COAD	Rictor →	-1.370	-3.313	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MEK1 by ZFPM1 expression — COAD

Explore this box plot interactively →