Q-omics provides the consensus-scored WDR91 profile across patient tissues and cancer cell-line models. WDR91 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, WDR91 is differentially expressed in 13, with the highest sampling consensus in HNSC. Additionally, WDR91 protein abundance shows 26,603 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight HNSC, and LSCC as cancer lineages where WDR91 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for WDR91 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes WDR91 survival associations across molecular data types. WDR91 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (6) and mass-spec protein abundance (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible WDR91 RNA expression–survival associations across cancer types. High WDR91 expression shows unfavorable associations in HNSC, LIHC, COAD and KICH, but favorable associations in ESCA and ACC. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify HNSC as the clearest survival context for WDR91 RNA expression.
This table summarizes WDR91 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 11. The strongest signals are observed in KIRC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for WDR91. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. WDR91 shows lower tumor expression in KICH and higher tumor expression in HNSC, KIRC, LIHC, BLCA and KIRP. The HNSC box plot shows higher WDR91 RNA expression in tumor versus normal tissue (log2 FC = +1.402, t-test p < 0.001).
This table shows molecular features associated with WDR91 in patient tissues and cancer cell lines. In patient samples, WDR91 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, WDR91 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in OESOPHAGUS and LARGE_INTESTINE.
