Q-omics provides the consensus-scored WDR25 profile across patient tissues and cancer cell-line models. WDR25 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, WDR25 is differentially expressed in 11, with the highest sampling consensus in KICH. Additionally, WDR25 RNA expression shows 18,295 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight UVM, KICH, and ACC as cancer lineages where WDR25 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for WDR25 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes WDR25 survival associations across molecular data types. WDR25 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (6) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible WDR25 RNA expression–survival associations across cancer types. High WDR25 expression shows unfavorable associations in UVM and ACC, but favorable associations in LGG, BRCA, KIRC and OV. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for WDR25 RNA expression.
This table summarizes WDR25 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 2. The strongest signals are observed in KICH for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for WDR25. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. WDR25 shows lower tumor expression in KICH and THCA and higher tumor expression in LIHC, HNSC, STAD and CHOL. The KICH box plot shows higher WDR25 RNA expression in normal versus tumor tissue (log2 FC = −1.210, t-test p < 0.001).
This table shows molecular features associated with WDR25 in patient tissues and cancer cell lines. In patient samples, WDR25 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, WDR25 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in CNS and UPPER_AERODIGESTIVE_TRACT.
