WDR25

Across TCGA cell cohorts, WDR25 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WDR25-associated genes across cancer lineages are TTLL8, TBC1D21, and ASCL3. Each is linked with WDR25 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR25-to-partner and partner-to-WDR25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL8 grouped by WDR25-low versus WDR25-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR25→partner) and Y-score (partner→WDR25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL8 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ASCL3 →	+0.143	+3.726	.005	.004	3	1
LARGE_INTESTINE	OR52H1 →	+0.027	+3.347	<.001	.005	3	1
LARGE_INTESTINE	ELOA3DP →	+0.034	+3.688	<.001	.002	3	1
SKIN	UGT2B10 →	+0.006	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

TTLL8 by WDR25 expression — LARGE_INTESTINE

Explore this box plot interactively →