WDR25

Across TCGA patient cohorts, WDR25 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR25-associated genes across cancer lineages are p27_pT198, ATM, and ERK2. Each is linked with WDR25 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR25-to-partner and partner-to-WDR25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by WDR25-low versus WDR25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR25→partner) and Y-score (partner→WDR25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.089	+2.222	.020	.010	3	2
UCEC	ATM →	-0.426	-1.925	.009	.005	3	2
UCEC	ERK2 →	+0.169	+2.115	.015	.017	3	1
UCEC	MEK1 →	+0.396	+2.321	.002	.001	3	1
UCEC	mTOR_pS2448 →	-0.124	-1.680	.021	.042	3	1
UCEC	Notch1 →	+0.123	+1.584	.014	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

p27_pT198 by WDR25 expression — UCEC

Explore this box plot interactively →