WDR25

Across TCGA patient cohorts, WDR25 mutation is significantly associated with the RNA expression of many other genes, with 1,697 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR25-associated genes across cancer lineages are RNA5SP163, RPS8P6, and CYCSP29. Each is linked with WDR25 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR25-to-partner and partner-to-WDR25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP163 grouped by WDR25-low versus WDR25-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR25→partner) and Y-score (partner→WDR25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNA5SP163 →	+0.414	+5.824	<.001	.001	3	2
COAD	RPS8P6 →	+0.176	+3.831	.001	.007	3	2
BLCA	CYCSP29 →	+0.196	+4.533	.002	.005	3	2
UCEC	TRIM36 →	+0.551	+2.423	.005	.001	3	2
UCEC	LSM11 →	+0.301	+2.425	.007	.001	2	3
UCEC	SUPV3L1 →	+0.309	+2.264	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,697 associations by consensus.

RNA5SP163 by WDR25 expression — COAD

Explore this box plot interactively →