WDR25

Across TCGA pan-cancer cohorts, WDR25 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WDR25 data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher WDR25 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated WDR25 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, HNSC, and LUAD are the cancer types where WDR25 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
HNSC	OS	Median	IV	0.079	0.733	<.001	12	view →
LUAD	OS	Median	All	0.254	0.697	.020	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	II,III,IV	0.922	0.438	.030	6	view →
READ	OS	Median	All	0.281	0.830	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

WDR25–THYM (OS)

Open the THYM breakdown →