Q-omics provides the consensus-scored WDR12 profile across patient tissues and cancer cell-line models. WDR12 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, WDR12 is differentially expressed in 17, with the highest sampling consensus in LUAD. Additionally, WDR12 protein abundance shows 31,784 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight LIHC, LUAD, and LSCC as cancer lineages where WDR12 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for WDR12 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes WDR12 survival associations across molecular data types. WDR12 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (4) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible WDR12 RNA expression–survival associations across cancer types. High WDR12 expression shows unfavorable associations in LIHC, ACC, KIRP, UVM and THCA, but favorable associations in KIRC. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for WDR12 RNA expression.
This table summarizes WDR12 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 17, while mass-spec protein shows differences in 9. The strongest signals are observed in LUAD for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for WDR12. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. WDR12 shows higher tumor expression in LUAD, COAD, BLCA, LIHC, LUSC and STAD. The LUAD box plot shows higher WDR12 RNA expression in tumor versus normal tissue (log2 FC = +1.213, t-test p < 0.001).
This table shows molecular features associated with WDR12 in patient tissues and cancer cell lines. In patient samples, WDR12 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, WDR12 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Lymphoma and BREAST.
