WDR12

Across TCGA patient cohorts, WDR12 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR12-associated genes across cancer lineages are JNK_pT183_Y185, p27_pT198, and Rab11. Each is linked with WDR12 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR12-to-partner and partner-to-WDR12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by WDR12-low versus WDR12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR12→partner) and Y-score (partner→WDR12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.177	-3.169	.029	.019	3	1
UCEC	p27_pT198 →	+0.126	+3.584	.014	.002	3	1
UCEC	Rab11 →	-0.143	-2.459	.042	.020	3	1
UCEC	Annexin-1 →	+0.547	+2.827	.031	.035	3	1
UCEC	S6_pS240_S244 →	+0.526	+2.459	.007	.020	3	1
UCEC	VHL →	-1.072	-3.459	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

JNK_pT183_Y185 by WDR12 expression — UCEC

Explore this box plot interactively →