WDR12

Across TCGA pan-cancer cohorts, WDR12 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of WDR12’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where WDR12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WDR12 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

LUAD, COAD, and BLCA are the cancer types where WDR12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDR12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+1.213	<.001	11	view →
COAD	Female	II,III,IV	+1.177	<.001	11	view →
BLCA	Male	All	+0.734	<.001	10	view →
LIHC	Male	II,III,IV	+0.980	<.001	9	view →
LUSC	Male	III,IV	+1.657	<.001	8	view →
STAD	Male	II,III,IV	+1.211	<.001	8	view →
HNSC	Male	IV	+0.900	<.001	8	view →
UCEC	All	All	+0.699	<.001	8	view →
READ	All	All	+1.095	<.001	7	view →
KIRP	All	II,III,IV	+0.589	<.001	7	view →
BRCA	All	II,III,IV	+0.342	<.001	6	view →
CHOL	Male	All	+2.045	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

WDR12–LUAD

Open the LUAD breakdown →