WASP family member 1Genealiases: NEDALVS · SCAR1 · WAVE · WAVE-1 · WAVE1
Q-omics provides the consensus-scored WASF1 profile across patient tissues and cancer cell-line models. WASF1 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, WASF1 is differentially expressed in 11, with the highest sampling consensus in HNSC. Additionally, WASF1 RNA expression shows 23,455 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight LIHC, HNSC, and LSCC as cancer lineages where WASF1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for WASF1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes WASF1 survival associations across molecular data types. WASF1 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (4) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible WASF1 RNA expression–survival associations across cancer types. High WASF1 expression shows unfavorable associations in LIHC, MESO, KIRP and HNSC, but favorable associations in KIRC and LGG. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for WASF1 RNA expression.
This table summarizes WASF1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 4. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for WASF1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. WASF1 shows higher tumor expression in HNSC, KIRC, KIRP, LUAD, LIHC and THCA. The HNSC box plot shows higher WASF1 RNA expression in tumor versus normal tissue (log2 FC = +1.155, t-test p < 0.001).
This table shows molecular features associated with WASF1 in patient tissues and cancer cell lines. In patient samples, WASF1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, WASF1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and BONE.
