vesicle associated membrane protein 5Genealiases: []
Q-omics provides the consensus-scored VAMP5 profile across patient tissues and cancer cell-line models. VAMP5 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, VAMP5 is differentially expressed in 12, with the highest sampling consensus in KIRC. Additionally, VAMP5 protein abundance shows 22,362 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight SKCM, KIRC, and LSCC as cancer lineages where VAMP5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for VAMP5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes VAMP5 survival associations across molecular data types. VAMP5 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (2) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible VAMP5 RNA expression–survival associations across cancer types. High VAMP5 expression shows unfavorable associations in LGG, but favorable associations in SKCM, THCA, UCEC, LUAD and LIHC. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for VAMP5 RNA expression.
This table summarizes VAMP5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 7. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for VAMP5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. VAMP5 shows lower tumor expression in KICH, LUAD, LUSC and BLCA and higher tumor expression in KIRC and LIHC. The KIRC box plot shows higher VAMP5 RNA expression in tumor versus normal tissue (log2 FC = +1.503, t-test p < 0.001).
This table shows molecular features associated with VAMP5 in patient tissues and cancer cell lines. In patient samples, VAMP5 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, VAMP5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Myeloma and BLOOD_Leukemia.
