VAMP5

Across TCGA patient cohorts, VAMP5 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAMP5-associated genes across cancer lineages are Tuberin, Notch1, and Rad50. Each is linked with VAMP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAMP5-to-partner and partner-to-VAMP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by VAMP5-low versus VAMP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAMP5→partner) and Y-score (partner→VAMP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.423	+3.169	.004	.020	3	1
UCEC	Notch1 →	+0.211	+3.169	.006	.020	2	1
UCEC	Rad50 →	-0.330	-3.169	.013	.020	2	1
UCEC	MEK1 →	+0.505	+3.169	.011	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Tuberin by VAMP5 expression — UCEC

Explore this box plot interactively →