VAMP5

Across TCGA pan-cancer cohorts, VAMP5 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated VAMP5 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher VAMP5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated VAMP5 expression acts as an unfavorable survival marker, although some lineages such as SKCM and THCA show a favorable association.

SKCM, THCA, and UCEC are the cancer types where VAMP5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.415	0.272	<.001	83	view →
THCA	DFS	Tertile	All	0.958	0.754	<.001	56	view →
UCEC	DFS	Quartile	II,III,IV	0.750	0.321	.006	52	view →
LUAD	DFS	Tertile	All	0.838	0.712	<.001	52	view →
LGG	DFS	Median	All	0.289	0.480	<.001	52	view →
LIHC	DFS	Quartile	All	0.625	0.402	.001	32	view →
CESC	OS	Median	II,III,IV	0.771	0.373	.002	28	view →
SARC	DFS	Tertile	All	0.632	0.336	<.001	28	view →
LUSC	DFS	Median	III,IV	0.518	0.225	.006	25	view →
HNSC	OS	Quartile	IV	0.779	0.529	.004	25	view →
GBM	DFS	Quartile	All	0.151	0.486	<.001	22	view →
STAD	OS	Tertile	IV	0.190	0.662	.017	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

VAMP5–SKCM (OS)

Open the SKCM breakdown →