vesicle associated membrane protein 2Genealiases: NEDHAHM · SYB2 · VAMP-2
Q-omics provides the consensus-scored VAMP2 profile across patient tissues and cancer cell-line models. VAMP2 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, VAMP2 is differentially expressed in 14, with the highest sampling consensus in KICH. Additionally, VAMP2 RNA expression shows 18,619 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRP, KICH, and ACC as cancer lineages where VAMP2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for VAMP2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes VAMP2 survival associations across molecular data types. VAMP2 RNA expression shows survival associations in the most cancer types (25). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible VAMP2 RNA expression–survival associations across cancer types. High VAMP2 expression shows favorable associations in KIRP, KIRC, LGG, MESO, PAAD and UVM. The KIRP Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for VAMP2 RNA expression.
This table summarizes VAMP2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for VAMP2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. VAMP2 shows lower tumor expression in KICH, BLCA, THCA, LUSC, LUAD and KIRP. The KICH box plot shows higher VAMP2 RNA expression in normal versus tumor tissue (log2 FC = −1.674, t-test p < 0.001).
This table shows molecular features associated with VAMP2 in patient tissues and cancer cell lines. In patient samples, VAMP2 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, VAMP2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in LIVER and BLOOD_Leukemia.
