Across TCGA patient cohorts, VAMP2 mutation is significantly associated with the RNA expression of many other genes, with 373 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAMP2-associated genes across cancer lineages are RNA5SP46, RNA5SP410, and RNA5SP422. Each is linked with VAMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAMP2-to-partner and partner-to-VAMP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAMP2→partner) and Y-score (partner→VAMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP46 →	+0.756	+5.669	<.001	.003	3	2
UCEC	RNA5SP410 →	+0.707	+2.526	<.001	.007	3	2
UCEC	RNA5SP422 →	+0.870	+2.408	<.001	.009	3	2
UCEC	RNA5SP415 →	+0.485	+2.681	.007	.008	3	2
BLCA	PRAMEF36P →	+0.029	+7.640	<.001	.009	3	2
UCEC	URGCP-MRPS24 →	+0.216	+2.969	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 373 associations by consensus.

Exploration

VAMP2 survival (RNA) · tumor vs normal (RNA) · all VAMP2 data types