Across TCGA patient cohorts, VAMP2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAMP2-associated genes across cancer lineages are A-Raf_pS299, Mre11, and p62 Lck ligand. Each is linked with VAMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAMP2-to-partner and partner-to-VAMP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAMP2→partner) and Y-score (partner→VAMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.174	-3.000	.011	.037	3	1
UCEC	Mre11 →	-0.101	-3.000	.042	.037	3	1
UCEC	p62 Lck ligand →	+0.375	+3.000	.046	.037	3	1
UCEC	AR →	-0.522	-3.000	.015	.037	3	1
UCEC	Bcl-2 →	-0.427	-2.973	.033	.037	3	1
UCEC	Rab25 →	-0.445	-3.000	.020	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

VAMP2 survival (RNA) · tumor vs normal (RNA) · all VAMP2 data types