USO1 vesicle transport factorGenealiases: P115 · TAP · VDP
Q-omics provides the consensus-scored USO1 profile across patient tissues and cancer cell-line models. USO1 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, USO1 is differentially expressed in 9, with the highest sampling consensus in KIRC. Additionally, USO1 protein abundance shows 21,634 significant protein co-abundance associations, with the highest sampling consensus in CCRCC. Together, these results highlight KIRC, and CCRCC as cancer lineages where USO1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for USO1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes USO1 survival associations across molecular data types. USO1 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (6) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible USO1 RNA expression–survival associations across cancer types. High USO1 expression shows unfavorable associations in CESC and LGG, but favorable associations in KIRC, UCS, COAD and UCEC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for USO1 RNA expression.
This table summarizes USO1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9, while mass-spec protein shows differences in 7. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for USO1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. USO1 shows lower tumor expression in THCA and UCEC and higher tumor expression in KIRC, LUAD, BRCA and CHOL. The KIRC box plot shows higher USO1 RNA expression in tumor versus normal tissue (log2 FC = +0.674, t-test p < 0.001).
This table shows molecular features associated with USO1 in patient tissues and cancer cell lines. In patient samples, USO1 shows the broadest associations at the RNA and protein expression levels, with CCRCC recurring as the lineage with the largest associated feature set. In cancer cell lines, USO1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in CNS and LUNG_NSCLC_LUAD.
